Publications & Preprints
24. Narayan, A. R. H. “Enzymes trapped and zapped for use outside cells” Nature 2019 DOI: 10.1038/d41586-019-00761-2 (News & Views).
23. Baker Dockrey, S. A. and Narayan, A. R. H. “Flavin-dependent biocatalysts in synthesis” Tetrahedron 2019 DOI: 10.1016/j.tet.2019.01.008 (Special Issue on Biocatalysis in Organic Synthesis).
22. Lukowski, A. L.. and Narayan, A. R. H. “Natural voltage-gated sodium channel ligands: Biosynthesis and biology” ChemBioChem 2019 DOI: 10.1002/cbic.201800754 (Special Issue: New Talent).
21. Benítez, Attabey Rodríguez; Tweedy, Sara; Dockrey, Summer A. Baker; Lukowski, April L.; Wymore, Troy; Khare, Dheeraj; Brooks L. Charles III; Smith Janet L.; Narayan Alison R.H. (2018): Structural Basis for Selectivity in Flavin-Dependent Monooxygenase-Catalyzed Oxidative Dearomatization. ChemRxiv. Preprint. DOI:0.26434/chemrxiv.7297766.v1
20. Baker Dockrey, S. A.; Doyon, T. J.; Perkins, J. C.; Narayan, A. R. H. “Whole-cell biocatalysis platform for gram-scale oxidative dearomatization of phenols”Chem. Biol. Drug Des. 2018 DOI:10.1111/cbdd.13443.
19. Lukowski, A. L.; Ellinwood, D. C.; Hinze, M. E.; DeLuca, R. J.; Du Bois, J.; Hall, S.; Narayan, A. R. H. "C–H hydroxylation in paralytic shellfish toxin biosynthesis" J. Am. Chem. Soc., 2018, 140 (37), 11863–11869 DOI: 10.1021/jacs.8b08901
18. Chun, S. W.; Hinze, M. E.; Skiba, M. A.; Narayan, A. R. H. "Chemistry of a unique polyketide-like synthase" J. Am. Chem. Soc. 2018, 140, 2430-2433. DOI: 10.1021/jacs.7b13297.
*Highlighted by Nature Product Reports, Hot off the press.
17. Baker Dockrey, S. A.; Lukowski, A. L.; Becker, M. R.; Narayan, A. R. H. “Biocatalytic site- and enantioselective oxidative dearomatization of phenols” Nature Chem. 2018, 10, 119-125. DOI: 10.1038/nchem.2879.
*Featured in Chemical & Engineering News
*Highlighted by Synfacts.
*Highlighted by Nature Product Reports, Hot off the press.
(Mentored Publications)
16. Gilbert, M. M.; DeMars, M. D.; Yang, S.; Grandner, J. M.; Wang, S.; Wang, H.; Narayan, A. R. H.; Sherman, D. H.; Houk, K. N.; Montgomery, J. "Synthesis of Diverse 11- and 12-Membered Macrolactones from a Common Linear Substrate Using a Single Biocatalyst” ACS Cent. Sci. 2017, 3, 1304-1310. DOI: 10.1021/acscentsci.7b00450.
15. Narayan, A. R. H.; Jiménez-Osés, G.; Liu, P.; Negretti, S.; Zhao, W.; Ramabhadr, R. O.; Furan, L.; Li, Z.; Yang, Y.-F.; Gilbert, M.; Podust, L. M.; Montgomery, J.; Houk, K. N.; Sherman, D. H. “Enzymatic Hydroxylation of an Unactivated Methylene C–H Bond Guided by Molecular Dynamics Simulations” Nature Chem. 2015, 7, 653-660.
14. Dutta, S.; Whicher, J. R.; Hansen, D. A.; Hale, W. A.; Chemler, J. A.; Narayan, A. R. N.; Hakansson, K.; Sherman, D. H.; Smith, J. L.; Skiniotis, G. “Structure of a modular polyketide synthase” Nature 2014, 510, 512-517.
13. Whicher, J. R.; Dutta, S.; Hansen, D. A.; Hale, W. A.; Chemler, J. A.; Narayan, A. R. N.; Hakansson, K.; Sherman, D. H.; Smith, J. L.; Skiniotis, G. “Structural rearrangements of a PKS module during its catalytic cycle” Nature 2014, 510, 560-564.
12. Negretti, S.*; Narayan, A. R. H.*; Chiou, K. C.; Kells, P. M.; Stachowski, J. L.; Hansen, D. A.; Podust, L. M.; Montgomery, J.; Sherman, D. H. “Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation” J. Am. Chem. Soc. 2014, 136, 4901-4904. *Denotes equal contribution
11. Heller, S. T.; Kiho, T.; Narayan, A. R. H.; Sarpong, R. “Protic Solvent Mediated Cycloisomerization of Quinoline and Isoquinoline Propargylic Carbinols: Syntheses of (±)-3-Demethoxyerythratidinone and (±)-Cocculidine” Angew. Chem. Int. Ed. 2013, 52, 11129-11133.
10. Hansen, D. H.; Rath, C. M.; Eisman, E. B.; Narayan, A. R. H.; Kittendorf, J. D.; Mortison, J. D.; Yoon, Y. J.; Sherman, D. H. “Biocatalytic Synthesis of Pikromycin, Methymycin, Neomethymycin, Novamethymycin, and Ketomethymycin” J. Am. Chem. Soc. 2013, 135, 11232-11238.
9. Narayan, A. R. H.; Sherman, D. H. “Re-engineering nature’s catalysts” Science 2013, 339, 283-284.
8. Hardin Narayan, A. R.; Sarpong, R. "Indolizinones as Synthetic Scaffolds: Fundamental Reactivity and the Relay of Stereochemical Information" Org. Biomol. Chem. 2012, 10, 70-78.
7. Hardin Narayan, A. R.; Sarpong, R. “Remarkable Facilitation of Hetero-Cycloisomerizations with Water and Other Polar Protic Solvents: Metal-Free Synthesis of Indolizines” Green Chem. 2010, 10, 1556-1559.
6. Hardin Narayan, A. R.; Simmons, E. R.; Sarpong, R. “Synthetic strategies toward the cortistatin family of natural products” Eur. J. Org. Chem. 2010, 3553-3567.
5. Simmons, E. M.; Hardin, A. R.; Guo, X.; Sarpong, R. "Formal total synthesis of (±)-cortistatin A" Tetrahedron 2010, 66, 4696-4700.
4. Simmons, E. M.; Hardin, A. R.; Guo, X.; Sarpong, R. “Rapid Construction of the Cortistatin Pentacyclic Core” Angew. Chem. Int. Ed. 2008, 47, 6650 – 6653.
3. Hardin, A. R.; Sarpong, R. "Electronic Effects in the Pt-Catalyzed Cycloisomerization of Propargylic Esters: Synthesis of 2,3-Disubstituted Indolizines as a Mechanistic Probe" Org. Lett. 2007, 9, 4547-4550.
2. Adams, J.; Hardin, A. R.; Vounatsos, F. “Microwave-Assisted Synthesis of New Polysubstituted Dienaminoesters and Their Cyclization to 3-Bromo-2(1H)-Pyridinones” J. Org. Chem. 2006, 71, 9895-9898.
1. Hay, M.; Hardin, A. R.; Wolfe, J. P. “Palladium-Catalyzed Synthesis of Tetrahydrofurans from γ-Hydroxy Terminal Alkenes: Scope, Limitations, and Stereoselectivity” J. Org. Chem. 2005, 70, 3099-3107.